Sammanfattning

Albendazole (ABZ) is used as an anthelmintic drug in humans and animals. ABZ has been shown to cause developmental toxicity in experimental animals, however it is not clear if this is caused by the parent compound or a metabolite. Zebrafish embryos were exposed from 1 to 144 hpf (hours post fertilization) to investigate the developmental toxicity of ABZ, the first metabolite albendazole sulphoxide and the subsequent metabolites albendazole sulphone (ABZSO(2)) and albendazole-2-aminosulphone (ABZSO(2)NH(2)). The results showed that ABZ caused malformations of head and tail and embryonic lethality from 0.3 mu M. In contrast, the metabolites did not display developmental toxicity at any tested concentration. Dechorionation did not influence the developmental toxic potential of ABZ and ABZSO, indicating that bioavailability was not a limiting factor. Chemical analysis showed that at sublethal concentrations, most of ABZ was metabolized to ABZSO. The results demonstrate that in zebrafish embryos ABZ rather than ABZSO displays developmental toxicity. (C) 2011 Elsevier Inc. All rights reserved.

Nyckelord

Benzimidazole; Embryotoxicity; Teratogenicity; Zebrafish; Dechorionation

Publicerad i

Reproductive Toxicology
2011, Volym: 32, nummer: 1, sidor: 129-137
Utgivare: PERGAMON-ELSEVIER SCIENCE LTD

SLU författare

• Carlsson, Gunnar

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Patring, Johan

  • Institutionen för vatten och miljö, Sveriges lantbruksuniversitet
    

• Ullerås, Erik

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Oskarsson, Agneta

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Miljö- och naturvårdsvetenskap


Publikationens identifierare

DOI: https://doi.org/10.1016/j.reprotox.2011.05.015

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/57203