Sammanfattning

Metacaspases are cysteine-dependent proteases found in protozoa, fungi and plants and are distantly related to metazoan caspases. Although metacaspases share structural properties with those of caspases, they lack Asp specificity and cleave their targets after Arg or Lys residues. Studies performed over the past 10 years have demonstrated that metacaspases are multifunctional proteases essential for normal physiology of non-metazoan organisms. This article provides a comprehensive overview of the metacaspase function and molecular regulation during programmed cell death, stress and cell proliferation, as well as an analysis of the first metacaspase-mediated proteolytic pathway. To prevent further misapplication of caspase-specific molecular probes for measuring and inhibiting metacaspase activity, we provide a list of probes suitable for metacaspases. Cell Death and Differentiation (2011) 18, 1279-1288; doi:10.1038/cdd.2011.66; published online 20 May 2011

Nyckelord

metacaspase; substrate specificity; caspase; cell proliferation; protein aggregation; in vivo degradome

Publicerad i

Cell Death and Differentiation
2011, Volym: 18, nummer: 8, sidor: 1279-1288
Utgivare: NATURE PUBLISHING GROUP

SLU författare

• Zavialov, Anton

  • Institutionen för molekylärbiologi, Sveriges lantbruksuniversitet
    

• Bozhkov, Peter

  • Institutionen för växtbiologi, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Jordbruksvetenskap
Livsmedelsvetenskap


Publikationens identifierare

DOI: https://doi.org/10.1038/cdd.2011.66

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/58980