Sammanfattning

The scientific literature on altered onset of puberty predominantly involves studies on females. This paper reviews current knowledge on the role of environmental pollutants in dysregulation of male puberty in humans, laboratory rodents and farm animals. The methods used to determine the onset of puberty are well developed in humans and farm animals, and standardized across studies in humans. In laboratory rodents standardized external morphological endpoints are used. There is an increasing weight of evidence from epidemiological studies in humans, as well as from experiments in animals, indicating that environmental pollutants dysregulate puberty in males. Most data are from studies on "classical" persistent environmental pollutants. Assessing the effect of multichemical environmental pollution on dysregulation of puberty in humans is more challenging; further solid epidemiological data would likely contribute most to our understanding, especially if combined with systematically collected field-data from selected wildlife. (C) 2014 The Authors. Published by Elsevier Inc. All rights reserved.

Nyckelord

Male puberty; Human F; arm animal; Rodent; Wildlife; Chemicals; Environmental pollution

Publicerad i

Reproductive Toxicology
2014, Volym: 44, sidor: 23-32

SLU författare

• Magnusson, Ulf

  • Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Klinisk vetenskap


Publikationens identifierare

DOI: https://doi.org/10.1016/j.reprotox.2013.08.002

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/66425