Härd, Torleif
- Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
Patent2009
Härd, Torleif; Sandberg, Anders
The invention provides monomeric and oligomeric amyloid beta peptide isomers that are resistant towards fibrillogenesis and their use as Screening reagents or antigens in methods
and pharmaceutical preparations for the treatment of
Alzheimer's disease and other conditions related to protein misfolding. The alanines at positions 21 and 30, in wild type amyloid beta peptide amino acid sequence, are according to
the invention replaced by cysteins, which results in an intra
molecular disulphide bond. The invention further provides transgenic animals expressing modified amyloid precursor proteins or amyloid beta peptides.
Ansökningsnummer: PCT/SE2009/050378
Patentnummer: WO/2009/128772
Datum för ansökan: 2009-10-22
Datum för publicering: 2009-10-22
Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)
Assignees:
HÄRD, Torleif [SE/SE]; SE (UsOnly)
SANDBERG, Anders [SE/SE]; SE (UsOnly)
MIVAC DEVELOPMENT AKTIEBOLAG [SE/SE]; Göteborg, SE (AllExceptUS)
https://res.slu.se/id/publ/66724