Karlsson Tiselius, Andreas
- Institutionen för molekylärbiologi, Sveriges lantbruksuniversitet
Forskningsartikel2003Vetenskapligt granskad
Karlsson A, Parales JV, Parales RE, Gibson DT, Eklund H, Ramaswamy S
Binding of oxygen to iron is exploited in several biological and chemical processes. Although computational and spectroscopic results have suggested side-on binding, only end-on binding of oxygen to iron has been observed in crystal structures. We have determined structures of naphthalene dioxygenase that show a molecular oxygen species bound to the mononuclear iron in a side-on fashion. In a complex with substrate and dioxygen, the dioxygen molecule is lined up for an attack on the double bond of the aromatic substrate. The structures reported here provide the basis for a reaction mechanism and for the high stereospecificity of the reaction catalyzed by naphthalene dioxygenase
Science
2003, Volym: 299, nummer: 5609, sidor: 1039-1042
Utgivare: AMER ASSOC ADVANCEMENT SCIENCE
Miljö- och naturvårdsvetenskap
DOI: https://doi.org/10.1126/science.1078020
https://res.slu.se/id/publ/796