Forskningsartikel2009Vetenskapligt granskadÖppen tillgång
Imprinting of the Polycomb Group Gene MEDEA Serves as a Ploidy Sensor in Arabidopsis
Erilova, Aleksandra; Brownfield, Lynette; Exner, Vivien; Rosa, Marisa; Twell, David; Scheid, Ortrun Mittelsten; Hennig, Lars; Koehler, Claudia
Sammanfattning
Balanced maternal and paternal genome contributions are a requirement for successful seed development. Unbalanced contributions often cause seed abortion, a phenomenon that has been termed "triploid block.'' Misregulation of imprinted regulatory genes has been proposed to be the underlying cause for abnormalities in growth and structure of the endosperm in seeds with deviating parental contributions. We identified a mutant forming unreduced pollen that enabled us to investigate direct effects of unbalanced parental genome contributions on seed development and to reveal the underlying molecular mechanism of dosage sensitivity. We provide evidence that parent-of-origin-specific expression of the Polycomb group (PcG) gene MEDEA is causally responsible for seed developmental aberrations in Arabidopsis seeds with increased paternal genome contributions. We propose that imprinted expression of PcG genes is an evolutionary conserved mechanism to balance parental genome contributions in embryo nourishing tissues.
Publicerad i
PLoS Genetics
2009, Volym: 5, nummer: 9, artikelnummer: e1000663
Utgivare: PUBLIC LIBRARY SCIENCE
UKÄ forskningsämne
Botanik
Publikationens identifierare
DOI: https://doi.org/10.1371/journal.pgen.1000663
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/84522