Sammanfattning

Pituitary dwarfism in German shepherd dogs is characterized by combined pituitary hormone deficiency (CPHD) and intrapituitary cyst formation. Activation of the leukemia inhibitory factor (LIF)-LIF receptor (LIFR) signal transduction pathway results in a similar phenotype in (transgenic) mice. We therefore assessed the role of the LIFR in the etiology of pituitary dwarfism in German shepherd dogs. A polymorphic microsatellite marker (UULIFR) was used to analyze the segregation of the LIFR gene in 22 German shepherd dogs from 4 pedigrees, each including one dwarf. There was no allelic association between UULIFR and the dwarfism phenotype. Based on our findings LIFR was excluded as a candidate gene for CPHD. (c) 2006 Elsevier Ltd. All rights reserved.

Nyckelord

congenital growth hormone deficiency; canine

Publicerad i

Research in Veterinary Science
2006, Volym: 81, nummer: 3, sidor: 316-320

UKÄ forskningsämne

Klinisk vetenskap


Publikationens identifierare

DOI: https://doi.org/10.1016/j.rvsc.2006.03.001

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/86238