Sammanfattning

The Atlantic herring is one of the most abundant vertebrates on earth but its nucleotide diversity is moderate (pi = 0.3%), only three-fold higher than in human. Here, we present a pedigree-based estimation of the mutation rate in this species. Based on whole-genome sequencing of four parents and 12 offspring, the estimated mutation rate is 2.0 x 10(-9) per base per generation. We observed a high degree of parental mosaicism indicating that a large fraction of these de novo mutations occurred during early germ cell development. The estimated mutation rate the lowest among vertebrates analyzed to date - partially explains the discrepancy between the rather low nucleotide diversity in herring and its huge census population size. But a species like the herring will never reach its expected nucleotide diversity because of fluctuations in population size over the millions of years it takes to build up high nucleotide diversity.

Nyckelord

Atlantic herring; Clupea harengus; genetics; mutation rates; nucleotide diversity; whole-genome sequencing

Publicerad i

eLife
2017, Volym: 6, artikelnummer: e23907
Utgivare: ELIFE SCIENCES PUBLICATIONS LTD

SLU författare

• Casini, Michele

  • Institutionen för akvatiska resurser (SLU Aqua), Sveriges lantbruksuniversitet
    

• Andersson, Leif

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    
  • Texas A&M University
  • Uppsala universitet

UKÄ forskningsämne

Evolutionsbiologi


Publikationens identifierare

DOI: https://doi.org/10.7554/eLife.23907

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/92564