Forskningsartikel2024Vetenskapligt granskadÖppen tillgång

Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4+ and CD8+ T Cells, and Skin Mast Cells by Quantitative Transcriptomics

Akula, Srinivas; Alvarado-Vazquez, Abigail; Mendez Enriquez, Erika Haide.

Forskningsartikel2024Vetenskapligt granskadÖppen tillgång

Disruption of the mast cell carboxypeptidase A3 gene does not attenuate airway inflammation and hyperresponsiveness in two mouse models of asthma

Waern, Ida; Akula, Srinivas; Allam, Venkata Sita Rama Raju et al.

Forskningsartikel2024Vetenskapligt granskadÖppen tillgång

Cultures of Human Skin Mast Cells, an Attractive In Vitro Model for Studies of Human Mast Cell Biology

Akula, Srinivas; Tripathi, Shiva Raj; Franke, Kristin et al.

Forskningsartikel2024Vetenskapligt granskadÖppen tillgång

Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice

Allam, Venkata Sita Rama Raju; Akula, Srinivas; Waern, Ida et al.

Forskningsartikel2023Vetenskapligt granskadÖppen tillgång

Two granzyme A/K homologs in Zebra mbuna have different specificities, one classical tryptase and one with chymase activity

Aybay, Erdem; Elkhalifa, Mamoun; Akula, Srinivas et al.

Forskningsartikel2023Vetenskapligt granskadÖppen tillgång

Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity

Aybay, Erdem; Ryu, Jinhye; Fu, Zhirong et al.

Forskningsartikel2023Vetenskapligt granskadÖppen tillgång

Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity

Allam, Venkata Sita Rama Raju; Waern, Ida; Taha, Sowsan et al.

Forskningsartikel2023Vetenskapligt granskadÖppen tillgång

Single-cell transcriptomics delineates the immune cell landscape in equine lower airways and reveals upregulation of FKBP5 in horses with asthma

Riihimaki, Miia; Fegraeus, Kim; Nordlund, Jessica et al.

Forskningsartikel2022Vetenskapligt granskadÖppen tillgång

Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases

Akula, Srinivas; Hellman, Lars; Aviles, Francesc Xavier et al.

Forskningsartikel2022Vetenskapligt granskadÖppen tillgång

The Human Monocyte-A Circulating Sensor of Infection and a Potent and Rapid Inducer of Inflammation

Lara, Sandra; Akula, Srinivas; Fu, Zhirong et al.

Forskningsartikel2022Vetenskapligt granskadÖppen tillgång

Quantitative Analysis of the Transcriptome of Two Commonly Used Human Monocytic Cell Lines-THP-1 and Mono Mac 6-Reveals Their Arrest during Early Monocyte/Neutrophil Differentiation

Akula, Srinivas; Lara, Sandra; Olsson, Anna-Karin et al.

Översiktsartikel2022Vetenskapligt granskadÖppen tillgång

Mast Cell and Basophil Granule Proteases-In Vivo Targets and Function

Hellman, Lars; Akula, Srinivas; Fu, Zhirong et al.

Forskningsartikel2022Vetenskapligt granskadÖppen tillgång

Quantitative Transcriptome Analysis of Purified Equine Mast Cells Identifies a Dominant Mucosal Mast Cell Population with Possible Inflammatory Functions in Airways of Asthmatic Horses

Akula, Srinivas; Riihimäki, Miia; Waern, Ida et al.

Översiktsartikel2021Vetenskapligt granskadÖppen tillgång

The Evolutionary History of the Chymase Locus -a Locus Encoding Several of the Major Hematopoietic Serine Proteases

Akula, Srinivas; Fu, Zhirong; Wernersson, Sara et al.

Forskningsartikel2020Vetenskapligt granskadÖppen tillgång

Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33

Teufelberger, Andrea R.; Van Nevel, Sharon; Hulpiau, Paco et al.

Forskningsartikel2020Vetenskapligt granskadÖppen tillgång

How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells? A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells

Akula, Srinivas; Paivandy, Aida; Fu, Zhirong et al.

Forskningsartikel2020Vetenskapligt granskadÖppen tillgång

Protective role of mouse mast cell tryptase Mcpt6 in melanoma

Grujic, Mirjana; Hellman, Lars; Gustafson, Ann-Marie et al.

Forskningsartikel2020Vetenskapligt granskadÖppen tillgång

Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity

Akula, Srinivas; Paivandy, Aida; Fu, Zhirong et al.

Srinivas Akula

Publikationer

2024

Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4+ and CD8+ T Cells, and Skin Mast Cells by Quantitative Transcriptomics

Disruption of the mast cell carboxypeptidase A3 gene does not attenuate airway inflammation and hyperresponsiveness in two mouse models of asthma

Cultures of Human Skin Mast Cells, an Attractive In Vitro Model for Studies of Human Mast Cell Biology

Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice

2023

Two granzyme A/K homologs in Zebra mbuna have different specificities, one classical tryptase and one with chymase activity

Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity

Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity

Single-cell transcriptomics delineates the immune cell landscape in equine lower airways and reveals upregulation of FKBP5 in horses with asthma

2022

Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases

The Human Monocyte-A Circulating Sensor of Infection and a Potent and Rapid Inducer of Inflammation

Quantitative Analysis of the Transcriptome of Two Commonly Used Human Monocytic Cell Lines-THP-1 and Mono Mac 6-Reveals Their Arrest during Early Monocyte/Neutrophil Differentiation

Mast Cell and Basophil Granule Proteases-In Vivo Targets and Function

Quantitative Transcriptome Analysis of Purified Equine Mast Cells Identifies a Dominant Mucosal Mast Cell Population with Possible Inflammatory Functions in Airways of Asthmatic Horses

2021

The Evolutionary History of the Chymase Locus -a Locus Encoding Several of the Major Hematopoietic Serine Proteases

2020

Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33

How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells? A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells

Protective role of mouse mast cell tryptase Mcpt6 in melanoma

Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity