Forskningsartikel2011Vetenskapligt granskadÖppen tillgång
The interplay between SUCLA2, SUCLG2, and mitochondrial DNA depletion
Miller, C.; Wang, Liya; Östergaard, E. et al.
Publikationer
2011
2010
Forskningsartikel2010Vetenskapligt granskadÖppen tillgång
Upregulation of thymidine kinase activity compensates for loss of thymidylate synthase activity in Mycoplasma pneumoniae
Wang, Liya; Hames, Claudine; Schmidl, Sebastian R. et al.
Forskningsartikel2010Vetenskapligt granskad
Tissue Specific Distribution of Pyrimidine Deoxynucleoside Salvage Enzymes Shed Light on the Mechanism of Mitochondrial DNA Depletion
Wang, Liya; Eriksson, Staffan.
Forskningsartikel2010Vetenskapligt granskad
Identification and Characterization of Mitochondrial Factors Modulating Thymidine Kinase 2 Activity
Sun, Ren; Eriksson, Staffan; Wang, Liya.
Forskningsartikel2010Vetenskapligt granskad
Deoxynucleoside Salvage Enzymes and Tissue Specific Mitochondrial DNA Depletion
Wang, Liya.
Forskningsartikel2010Vetenskapligt granskad
Thymidylate synthases of Mycoplasma mycoides subsp mycoides SC and Ureaplasma parvum are flavin-dependent
Wehelie, Rahma; Eriksson, Staffan; Bölske, G et al.
Forskningsartikel2010Vetenskapligt granskadÖppen tillgång
3 '-(1,2,3-Triazol-1-yl)-3 '-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations
Lin, Jay; Roy, V; Wang, Liya et al.
Forskningsartikel2010Vetenskapligt granskad
Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1
Welin M, Egeblad Louise, Johansson A, Stenmark P, Wang Liya, Flodin S, Nyman T, Tresaugues L, Kotenyova T, Johansson I, Eriksson Staffan, Eklund Hans, Nordlund P.
2008
Forskningsartikel2008Vetenskapligt granskad
5-bromovinyl 2'-deoxyuridine phosphorylation by mitochondrial and cytosolic thymidine kinase (TK2 and TK1) and its use in selective measurement of TK2 activity in crude extracts
Wang, Liya; Eriksson, Staffan.
Forskningsartikel2008Vetenskapligt granskad
Molecular mechanisms of mitochondrial DNA depletion diseases caused by deficiencies in enzymes in purine and pyrimidine metabolism
Eriksson, Staffan; Wang, Liya.
Forskningsartikel2008Vetenskapligt granskadÖppen tillgång
Mechanisms of substrate selectivity for Bacillus anthracis thymidylate kinase
Carnrot, Cecilia; Wang, Liya; Topalis, Dimitri et al.
2007
Forskningsartikel2007Vetenskapligt granskad
Structure-function analysis of a bacterial deoxyadenosine kinase reveals the basis for substrate specificity
Welin M, Wang LY, Eriksson S, Eklund H.
Forskningsartikel2007Vetenskapligt granskadÖppen tillgång
Structural studies of thymidine kinases from Bacillus anthracis and Bacillus cereus provide insights into quaternary structure and conformational changes upon substrate binding
Kosinska U, Carnrot C, Sandrini MPB, Clausen AR, Wang LY, Piskur J, Eriksson S, Eklund H.
Forskningsartikel2007Vetenskapligt granskadÖppen tillgång
Targeted transgenic overexpression of mitochondrial thymidine kinase (TK2) alters mitochondrial DNA (mtDNA) and mitochondrial polypeptide abundance - Transgenic TK2, mtDNA, and antiretrovirals
Hosseini SH, Kohler JJ, Haase CP, Tioleco N, Stuart T, Keebaugh E, Ludaway T, Russ R, Green E, Long R, Wang LY, Eriksson S, Lewis W.
Forskningsartikel2007Vetenskapligt granskad
The role of Ureaplasma nucleoside monophosphate kinases in the synthesis of nucleoside triphosphates
Wang, LY.
Forskningsartikel2007Vetenskapligt granskadÖppen tillgång
Structural and functional investigations of Ureaplasma parvum UMP kinase - a potential antibacterial drug target
Egeblad-Welin L, Welin M, Wang L, Eriksson S.
2006
Forskningsartikel2006Vetenskapligt granskad
Evaluation of Bacillus anthracis thymidine kinase as a potential target for the development of antibacterial nucleoside analogs
Carnrot C, Vogel SR, Byun Y, Wang LY, Tjarks W, Eriksson S, Phipps AJ.
Forskningsartikel2006Vetenskapligt granskad
Kinetic mechanism of deoxyadenosine kinase from Mycoplasma determined by surface plasmon resonance technology
Pol E, Wang LY.
2005
Forskningsartikel2005Vetenskapligt granskad
Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes
Wang LY, Limongelli A, Vila MR, Carrara F, Zeviani M, Eriksson S.
Forskningsartikel2005Vetenskapligt granskadÖppen tillgång
The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus
Ren H, Wang LY, Bennett M, Liang YH, Zheng XF, Lu F, Li LF, Nan J, Luo M, Eriksson S, Zhang CM, Su XD.
Forskningsartikel2005Vetenskapligt granskad
Structure of the substrate complex of thymidine kinase from Ureaplasma urealyticum and investigations of possible drug targets for the enzyme
Kosinska U, Carnrot C, Eriksson S, Wang L, Eklund H.
2004
Forskningsartikel2004Vetenskapligt granskad
Effect of fluoropyrimidines on the growth of Ureaplasma urealyticum
Wehelie, Rahma; Eriksson, Staffan; Wang, Liya.
Forskningsartikel2004Vetenskapligt granskadÖppen tillgång
Structures of thymidine kinase 1 of human and mycoplasmic origin
Welin M, Kosinska U, Mikkelsen NE, Carnrot C, Zhu CY, Wang LY, Eriksson S, Munch-Petersen B, Eklund H.
2003
Forskningsartikel2003Vetenskapligt granskad
Comparison of cytotoxicity of 2-chloro-2 '-arabino-fluoro-2 '-deoxyadenosine (clofarabine) with cladribine in mononuclear cells from patients with acute myeloid and chronic lymphocytic leukemia
Lindemalm S, Liliemark J, Gruber A, Eriksson S, Karlsson MO, Wang YY, Albertioni F.
Forskningsartikel2003Vetenskapligt granskad
Mitochondrial deoxyguanosine kinase mutations and mitochondrial DNA depletion syndrome
Wang, LY; Eriksson, S.
Forskningsartikel2003Vetenskapligt granskad
Molecular characterization of thymidine kinase from Ureaplasma urealyticum: nucleoside analogues as potent inhibitors of mycoplasma growth
Carnrot, C; Wehelie, R; Eriksson, S et al.
Forskningsartikel2003Vetenskapligt granskadÖppen tillgång
Kinetic properties of mutant human thymidine kinase 2 suggest a mechanism for mitochondrial DNA depletion myopathy
Wang LY, Saada A, Eriksson S.
2001
Forskningsartikel2001Vetenskapligt granskadÖppen tillgång
Antiviral Guanosine Analogs as Substrates for Deoxyguanosine Kinase: Implications for Chemotherapy
Herrström Sjöberg, Anita; Wang, Liya; Eriksson, Staffan.
Forskningsartikel2001Vetenskapligt granskadÖppen tillgång
Novel deoxynucleoside-phosphorylating enzymes in mycoplasmas: evidence for efficient utilization of deoxynucleosides
Wang, Liya; Westberg, Joakim; Bölske, Göran et al.
2000
Forskningsartikel2000Vetenskapligt granskadÖppen tillgång
Cloning and characterization of full-length mouse thymidine kinase 2: the N-terminal sequence directs import of the precursor protein into mitochondria
Wang, Liya; Eriksson, Staffan.
1999
Forskningsartikel1999Vetenskapligt granskadÖppen tillgång
Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates
Wang, Liya; Munch-Petersen, Birgitte; Herrström Sjöberg, Anita et al.
Forskningsartikel1999Vetenskapligt granskadÖppen tillgång
Cloning and characterization of mouse deoxyguanosine kinase : Evidence for a cytoplasmic isoform
Petrakis, Thodoris G.; Ktistaki, Eleni; Wang, Liya et al.
1998
Forskningsartikel1998Vetenskapligt granskad
Substrate specificity of human recombinant mitochondrial deoxyguanosine kinase with cytostatic and antiviral purine and pyrimidine analogs
Herrström Sjöberg, Anita; Wang, Liya; Eriksson, Staffan.
1997
Doktorsavhandling1997Öppen tillgång
Mitochondrial deoxyribonucleoside salvage enzymes : cloning and characterization of deoxyguanosine kinase and thymidine kinase
Wang, Liya.
Forskningsartikel1997Vetenskapligt granskad
Substrate Specificities, Expression and Primary Sequences of Deoxynucleoside Kinases; Implications for Chemotherapy
Eriksson, Staffan; Wang, Liya.
1996
Forskningsartikel1996Vetenskapligt granskadÖppen tillgång
Cloning and expression of human mitochondrial deoxyguanosine kinase cDNA
Eriksson, Staffan; Hellman, Ulf; Wang, Liya.
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