Skip to main content
SLU:s publikationsdatabas (SLUpub)

Forskningsartikel2006Vetenskapligt granskad

Early post-natal exposure to low dose oral di(2ethylhexyl) phthalate affects the peripheral LH-concentration in plasma, but does not affect mating behavior in the post-pubertal boar

Ljungvall, Karl; Spjuth, Linda; Hultén, Fredrik; Einarsson, Stig; Rodriguez, Heriberto; Andersson, Kjell; Magnusson, Ulf

Sammanfattning

In a split-litter design experiment, boars were exposed orally three times weekly to 300 mg/kg of di(2-ethylhexyl) phthalate (DEHP) between 3 and 7 weeks of age. Post-puberty, i.e. at 6 months of age the effects on endocrinology and mating behavior were examined. The response to stimulation with a synthetic GnRH-analogue at 9 months of age resulted initially in lower concentration of LH in the exposed animals, compared to the control animals. We did not find any effects of DEHP on the mating behavior. Also, the effects of DEHP during the treatment period on the plasma concentrations of testosterone, oestradiol and LH were examined. During the exposure period there was a transient decrease in plasma concentrations of LH in the control group, which did not occur in the boars exposed to DEHR The data suggest that DEHP in low repeated oral doses causes lasting effects on the hypothalamus-pituitary-gonadal axis. (c) 2005 Elsevier Inc. All rights reserved

Publicerad i

Reproductive Toxicology
2006, volym: 21, nummer: 2, sidor: 160-166
Utgivare: PERGAMON-ELSEVIER SCIENCE LTD

SLU författare

UKÄ forskningsämne

Klinisk vetenskap

Publikationens identifierare

  • DOI: https://doi.org/10.1016/j.reprotox.2005.07.012

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/10183