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Abstract

Background Dynamic laryngeal collapse (DLC) associated with poll flexion is the most common disorder of the upper respiratory tract (URT) in the Norwegian-Swedish Coldblooded Trotter (NSCT). The disorder, which has also been diagnosed in other breeds of trotters and gaited horses, appears to be related to anatomic phenotypes and only occurs during poll flexion when the horse is exercised 'on the bit'. Objectives Identify genomic regions associated with DLC in the NSCT by combining a rigorous phenotyping protocol with genomic data from a high-density equine genotyping array. Study design Prospective case/control study. Methods High-speed treadmill endoscopy was used to phenotype horses (n = 61) for DLC, distinguishing between cases and controls. Genome-wide association (GWA) analysis of DLC status was then performed using a principal component approach (PCA) with haplotype analyses subsequently performed for regions containing single-nucleotide polymorphisms (SNPs) above the suggestive genome-wide significance (GWS) threshold (P

Keywords

horse; genomic; harness racing; performance; upper respiratory tract disorder

Published in

Equine Veterinary Journal
2020, volume: 52, number: 2, pages: 174-180
Publisher: WILEY

SLU Authors

UKÄ Subject classification

Genetics and Breeding in Agricultural Sciences

Publication identifier

  • DOI: https://doi.org/10.1111/evj.13171

Permanent link to this page (URI)

https://res.slu.se/id/publ/102034