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Sammanfattning

Background Dynamic laryngeal collapse (DLC) associated with poll flexion is the most common disorder of the upper respiratory tract (URT) in the Norwegian-Swedish Coldblooded Trotter (NSCT). The disorder, which has also been diagnosed in other breeds of trotters and gaited horses, appears to be related to anatomic phenotypes and only occurs during poll flexion when the horse is exercised 'on the bit'. Objectives Identify genomic regions associated with DLC in the NSCT by combining a rigorous phenotyping protocol with genomic data from a high-density equine genotyping array. Study design Prospective case/control study. Methods High-speed treadmill endoscopy was used to phenotype horses (n = 61) for DLC, distinguishing between cases and controls. Genome-wide association (GWA) analysis of DLC status was then performed using a principal component approach (PCA) with haplotype analyses subsequently performed for regions containing single-nucleotide polymorphisms (SNPs) above the suggestive genome-wide significance (GWS) threshold (P

Nyckelord

horse; genomic; harness racing; performance; upper respiratory tract disorder

Publicerad i

Equine Veterinary Journal
2020, volym: 52, nummer: 2, sidor: 174-180
Utgivare: WILEY

SLU författare

UKÄ forskningsämne

Genetik och förädling inom lantbruksvetenskap

Publikationens identifierare

  • DOI: https://doi.org/10.1111/evj.13171

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/102034