Oskarsson, Agneta
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Abstract
The Panel on Food Additives and Flavourings (FAF Panel) of the European Food Safety Authority was requested to evaluate the genotoxic potential of the flavouring substances from subgroup 1.2.1 of FGE.19 in the Flavouring Group Evaluation 204 (FGE.204). In the present revision of this FGE (FGE.204Rev1), the FAF Panel evaluated new data provided by Industry following a request from the former Panel on Food Contact materials, Enzymes, Flavourings and Processing Aids (CEF Panel). This request followed from positive results in an invitro micronucleus test for clastogenicity and a negative result, but with no proof of bone marrow exposure, in an invivo micronucleus assay for the representative substance 7-methyl-3-octenone-2 [FL-no: 07.177]. Subsequently, the Industry submitted an invivo comet assay which was considered equivocal in the liver. The study was repeated confirming that 7-methyl-3-octenone-2 [FL-no: 07.177] did not induce primary DNA damage in the liver and duodenum. Based on the available data, the Panel concluded that the concern for genotoxicity can be ruled out for [FL-no: 07.177] and the 15 structurally related substances [FL-no: 02.102, 02.193, 07.044, 07.048, 07.082, 07.104, 07.105, 07.106, 07.107, 07.121, 07.139, 07.187, 07.188, 07.244, 07.258] which can be evaluated through the Procedure for flavouring substances. (C) 2019 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.
Keywords
FGE.19; subgroup 1.2.1; aliphatic; mono-unsaturated; alpha,beta-unsaturated ketones
Published in
EFSA Journal
2019, volume: 17, number: 7, article number: 5750
SLU Authors
UKÄ Subject classification
Public Health, Global Health and Social Medicine
Epidemiology
Publication identifier
- DOI: https://doi.org/10.2903/j.efsa.2019.5750
Permanent link to this page (URI)
https://res.slu.se/id/publ/104746