Bovine virus diarrhoea virus induces in vitro a proliferative response of peripheral blood mononuclear cells from cattle immunized by infection

Sammanfattning

The ability of bovine peripheral blood mononuclear cells (PBMC) to mount a proliferative response to bovine virus diarrhoea virus (BVDV) in vitro was examined. After culturing PBMC in the presence of a non-cytopathic strain of BVDV for 6 days, the magnitude of PBMC proliferation was measured as incorporation of radiolabelled thymidine, present during the last 18 h.Live, but not heat-inactivated, BVDV evoked a proliferative response of PBMC obtained from cattle seropositive to the virus. However, PBMC from seronegative or persistently BVDV-infected animals were not stimulated by BVDV. The presence of live BVDV did not alter the proliferative response of PBMC to stimulation with concanavalin A.

Publicerad i

Veterinary Microbiology
1992, volym: 31, nummer: 4, sidor: 317-325
Utgivare: ELSEVIER SCIENCE BV

SLU författare

• Fossum, Caroline

  • Institutionen för veterinärmedicinsk mikrobiologi, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Klinisk vetenskap

Publikationens identifierare

• DOI: https://doi.org/10.1016/0378-1135(92)90124-C

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/106569