Pejler, Gunnar
- Institutionen för molekylär biovetenskap, Sveriges lantbruksuniversitet
Sammanfattning
Snake or honeybee envenomation can cause substantial morbidity and mortality, and it has been proposed that the activation of mast cells by snake or insect venoms can contribute to these effects. We show, in contrast, that mast cells can significantly reduce snake-venom - induced pathology in mice, at least in part by releasing carboxypeptidase A and possibly other proteases, which can degrade venom components. Mast cells also significantly reduced the morbidity and mortality induced by honeybee venom. These findings identify a new biological function for mast cells in enhancing resistance to the morbidity and mortality induced by animal venoms.
Publicerad i
Science
2006, volym: 313, nummer: 5786, sidor: 526-530
Utgivare: AMER ASSOC ADVANCEMENT SCIENCE
SLU författare
Åbrink, Magnus
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
UKÄ forskningsämne
Veterinärmedicin
Husdjursvetenskap
Publikationens identifierare
- DOI: https://doi.org/10.1126/science.1128877
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/10689