Bezerra Lima Verde, Isabel
- Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
Sammanfattning
The emergence of community acquired infections increases the public health concern on K. pneumoniae and closely related bacteria among which antimicrobial resistance spreads. We report a multidrug-resistant K. pneumoniae isolate, B31, of a patient infected in the community and admitted to an intensive care unit in Northeast Brazil. Antimicrobial susceptibility and genome information were thoroughly investigated to characterize B31 in front of 172 sequenced strains of different countries. Assigned to the Sequence Type 15, which is globally spread, B31 presented extended spectrum beta-lactamase, tigecycline and ciprofloxacin resistance. Genome sequencing revealed most resistance genes being carried by plasmids with high dissemination potential. The absence of main virulence factors, like yersiniabactin and colibactin, apparently suggests a mild pathogenic strain which, on the contrary, persisted and caused severe infection in a previously healthy patient. The present study contributes to unveil the unclear genomic scenario of virulent and multidrug-resistant K. pneumoniae in Brazil.
Nyckelord
Klebsiella pneumoniae; Multilocus Sequence Type; Hospital Emergency Care; Phylogenomics; Antimicrobial Evaluation; Virulence Genes
Publicerad i
Gene
2021, volym: 772, artikelnummer: 145386
Utgivare: ELSEVIER
SLU författare
Globala målen (SDG)
SDG3 God hälsa och välbefinnande
UKÄ forskningsämne
Mikrobiologi inom det medicinska området
Medicinsk genetik och genomik
Publikationens identifierare
- DOI: https://doi.org/10.1016/j.gene.2020.145386
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/111098