Eriksson, Staffan
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
Sammanfattning
Thymidine kinase 1 (TK1) is an enzyme involved in the synthesis of DNA precursors. In studies using immunohistochemistry, it was reported to be a more useful proliferation marker than Ki-67 and PCNA in breast, lung and colorectal carcinoma. In this study, we extend the work of prior breast carcinoma studies by investigating the expression of TK1 in 132 patients with usual ductal hyperplasia (UDH), atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC). TK1 and Ki-67 expression were determined with monoclonal antibodies using the SP technique. The expression of TK1 was found to be significantly increased in the breast ductal carcinomas in the following manner: UDH
Nyckelord
thymidine kinase 1; Ki-67; ductal breast cancer; usual ductal hyperplasia; atypical ductal hyperplasia; ductal carcinoma in situ; invasive ductal carcinoma; immunohistochemistry
Publicerad i
Molecular Medicine Reports
2009, volym: 2, nummer: 6, sidor: 923-929
Utgivare: SPANDIDOS PUBL LTD
SLU författare
UKÄ forskningsämne
Läkemedelskemi
Publikationens identifierare
- DOI: https://doi.org/10.3892/mmr_00000193
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/118205