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Abstract

Background Mast cells (MCs) develop from a rare population of peripheral blood circulating MC progenitors (MCps). Here, we investigated whether the frequency of circulating MCps is altered in asthma patients sensitized to birch pollen during pollen season, compared to out of season.Methods Asthma patients were examined during birch pollen season in late April to early June (May), and out of season in November-January. Spirometry measurements, asthma and allergy-related symptoms, asthma control questionnaire (ACQ), and asthma control test (ACT) scores were assessed at both time points. The MCp frequency was determined by flow cytometry in ficoll-separated blood samples from patients with positive birch pollen-specific IgE, and analyzed in relation to basic and disease parameters.Results The frequency of MCps per liter of blood was higher in May than in November (p=.004), particularly in women (p=.009). Patients that reported moderate to severe asthma symptoms (

Keywords

asthma control; asthma symptoms; Betula; Fc epsilon RI; mast cell

Published in

Allergy
2023, volume: 78, number: 11, pages: 2959-2968
Publisher: WILEY

SLU Authors

UKÄ Subject classification

Respiratory Medicine and Allergy

Publication identifier

  • DOI: https://doi.org/10.1111/all.15860

Permanent link to this page (URI)

https://res.slu.se/id/publ/127584