Waern, Ida
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
Sammanfattning
Background Mast cells (MCs) develop from a rare population of peripheral blood circulating MC progenitors (MCps). Here, we investigated whether the frequency of circulating MCps is altered in asthma patients sensitized to birch pollen during pollen season, compared to out of season.Methods Asthma patients were examined during birch pollen season in late April to early June (May), and out of season in November-January. Spirometry measurements, asthma and allergy-related symptoms, asthma control questionnaire (ACQ), and asthma control test (ACT) scores were assessed at both time points. The MCp frequency was determined by flow cytometry in ficoll-separated blood samples from patients with positive birch pollen-specific IgE, and analyzed in relation to basic and disease parameters.Results The frequency of MCps per liter of blood was higher in May than in November (p=.004), particularly in women (p=.009). Patients that reported moderate to severe asthma symptoms (
Nyckelord
asthma control; asthma symptoms; Betula; Fc epsilon RI; mast cell
Publicerad i
Allergy
2023, volym: 78, nummer: 11, sidor: 2959-2968
Utgivare: WILEY
SLU författare
Wernersson, Sara
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
UKÄ forskningsämne
Lungmedicin och allergi
Publikationens identifierare
- DOI: https://doi.org/10.1111/all.15860
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/127584