Calcium-induced structural changes and domain autonomy in calmodulin

Sammanfattning

We have determined the solution structures of the apo and (Ca2+)(2) forms of the carboxy-terminal domain of calmodulin using multidimensional heteronuclear nuclear magnetic resonance spectroscopy, The results show that both forms adopt well-defined structures with essentially equal secondary structure, A comparison of the structures of the two forms shows that Ca2+ binding causes major rearrangements of the secondary structure elements with changes in inter-residue distances of up to 15 Angstrom and exposure of the hydrophobic interior of the four-helix bundle, Comparisons with previously determined high-resolution X-ray structures and models of calmodulin indicate that this domain is structurally autonomous.

Publicerad i

Nature Structural Biology
1995, volym: 2, nummer: 9, sidor: 777-783

SLU författare

• Finn, Bryan

  • Lunds Universitet

UKÄ forskningsämne

Fysikalisk kemi

Publikationens identifierare

• DOI: https://doi.org/10.1038/nsb0995-777

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/132597