Unveiling POM-peptide complexes: molecular insights into metal oxide nanoparticle-protein interactions

Sammanfattning

Mineral nanoparticles (NPs) play a crucial role in biological systems, exhibiting enzyme-like "nanozyme" activity in protein oxidation and hydrolysis. To study NP interactions at the molecular level, we characterized complexes of peptides with poly-oxo-metalate (POM) species, the smallest known NPs. Our findings highlight the importance of factors such as metal-oxygen bond polarity, peptide hydrophilicity, medium conditions, and structure-directing amino acids. Using single-crystal models and 2D NMR, we also explored interactions between larger NPs as nanozymes and proteins relevant for specific oxidation of amino acids and proteins.

Publicerad i

CrystEngComm
2025, volym: 27, nummer: 12, sidor: 1679-1686
Utgivare: ROYAL SOC CHEMISTRY

SLU författare

• Greijer, Björn

  • Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
    

• Kessler, Vadim

  • Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Oorganisk kemi

Publikationens identifierare

• DOI: https://doi.org/10.1039/d4ce01269k

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/141153