Speksnijder, Bent
- Institutionen för vatten och miljö, Sveriges lantbruksuniversitet
Sammanfattning
Pharmaceutical active compounds (PhACs) increasingly appear as complex mixtures in aquatic ecosystems, yet their bioconcentration in non-target organisms is poorly understood. This study examined tissue-specific distribution of five PhACs-bicalutamide, amitriptyline, furosemide, daidzein and sertraline-in signal crayfish (Pacifastacus leniusculus) after 96-hour exposure and an equal depuration period. Crayfish were subjected to environmentally relevant and 10-fold elevated mixture concentrations. Water and tissues (haemolymph, hepatopancreas, muscle) were analysed using ultra-high performance liquid chromatography-tandem mass spectrometry. Despite verified water concentrations and stable conditions, none of the compounds were quantifiable in tissues, except trace sertraline near the detection limit in some controls. The lack of detectable residues indicates minimal bioconcentration, likely due to physicochemical properties (low log Kow), rapid metabolism and efficient excretion. Results underscore the need for longer exposures and metabolite-focused studies to better assess environmental fate, tissue kinetics and potential risks of PhAC mixtures in freshwater invertebrates.
Nyckelord
Pharmaceuticals; Exposure; Tissue distribution; Mixtures; Aquatic invertebrates
Publicerad i
Environmental toxicology and pharmacology
2026, volym: 122, artikelnummer: 104935
Utgivare: ELSEVIER
SLU författare
Cerveny, Daniel
- Institutionen för vilt, fisk och miljö, Sveriges lantbruksuniversitet
- Institutionen för vilt, fisk och miljö, Sveriges lantbruksuniversitet
Golovko, Oksana
- Institutionen för vatten och miljö, Sveriges lantbruksuniversitet
- Institutionen för vatten och miljö, Sveriges lantbruksuniversitet
UKÄ forskningsämne
Miljövetenskap
Publikationens identifierare
- DOI: https://doi.org/10.1016/j.etap.2026.104935
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/145997