Uvnäs-Moberg, Kerstin
- Institutionen för tillämpad husdjursvetenskap och välfärd, Sveriges lantbruksuniversitet
Sammanfattning
The elegant work by Maejima et al. recently published in Aging Cell reveals a previously unrecognized mechanism linking age-related oxytocin (OXT) decline to epigenetic remodeling, mitochondrial dysfunction, and systemic inflammation (Maejima et al. 2025). Beyond documenting this relationship, the authors demonstrate its remarkable reversibility through nasal OXT administration. These findings provide the first molecular evidence supporting what has long been proposed: that the OXT system functions as a fundamental long-term regulator of health across the entire lifespan, from early development through aging (Moberg 2024, 2003; Uvnas-Moberg 1998). The current work now gives a tantalizing glimpse into the epigenetic mechanism behind this life course regulation.
Nyckelord
DNA methylation; early life programming; epigenetic aging; HPA axis; lifecourse epidemiology; noradrenergic/sympathetic nervous system; oxytocin; personalized epigenetic medicine; social connection; TET enzymes
Publicerad i
Aging Cell
2026, volym: 25, nummer: 2, artikelnummer: e70363
Utgivare: WILEY
SLU författare
UKÄ forskningsämne
Cellbiologi
Medicinsk epigenetik och epigenomik
Publikationens identifierare
- DOI: https://doi.org/10.1111/acel.70363
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/146414