Multivariate data analysis for enhanced interpretation of electrochemical impedance spectra of gramicidin-ion interactions in phospholipid monolayers

Lindholm-Sethson, B; Geladi, P; Koeppe, RE; Jonsson, O; Nilsson, D; Nelson, A

doi:10.1021/la062850j

Sammanfattning

This article describes a multifrequency electrochemical impedance study of phospholipid monolayers on a mercury drop electrode in solutions containing electrolytes and gramicidin derivatives: gramicidin A (gA), gramicidin-BOC (g-BOC), and desformylgramicidin (g-des). The impedance spectra have been studied individually (univariate approach) and also transformed using a multivariate data reduction method (multivariate approach). It was shown that the two approaches are complementary. Thus the formation of K+-conducting channels is observed in gA only, and these channels can be distinguished from an interaction of all gramicidin derivatives with Mg2+. An unknown peptide interaction in the monolayer was observed on a slow time scale

Publicerad i

Langmuir
2007, volym: 23, nummer: 9, sidor: 5029-5032
Utgivare: AMER CHEMICAL SOC

SLU författare

Geladi, Paul
- Institutionen för skogens biomaterial och teknologi, Sveriges lantbruksuniversitet

UKÄ forskningsämne

Fysikalisk kemi

Publikationens identifierare

DOI: https://doi.org/10.1021/la062850j

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/17279