Åman, Per
- Department of Molecular Sciences, Swedish University of Agricultural Sciences
Abstract
The short-term effects of rye bran bread intake in prostate cancer were investigated. Ten men with conservatively treated prostate cancer were randomised to a daily supplement of 295 g of rye bran bread and eight men to 275 g of wheat bread (control) with similar fibre content for three weeks. Blood samples, ultrasound-guided core biopsies of the prostate, and urine samples were taken. In the rye group, there was a significant increase in plasma enterolactone, and the apoptotic index increased significantly from 2.1% (SD 1.3) to 5.9% (SD 1.8), P<0.005 as measured by a TUNEL index in four cases in the rye group and seven cases in the control group. Besides a significant decrease in weight in both groups, only small changes were observed in plasma concentrations of prostate specific antigen (PSA), circulating sex hormones, excreted oestrogens, insulin-like growth factor (IGF)-1, and in the endothelial fibrinolytical system. High intake of rye bran bread is suggested to increase apoptosis in prostate tumours. (C) 2003 Lippincott Williams Wilkins.
Keywords
apoptosis; phytoestrogens; prostate cancer; rye bran bread
Published in
European Journal of Cancer Prevention
2003, volume: 12, number: 5, pages: 407-415
Publisher: LIPPINCOTT WILLIAMS & WILKINS
SLU Authors
UKÄ Subject classification
Food Science
Publication identifier
- DOI: https://doi.org/10.1097/00008469-200310000-00010
Permanent link to this page (URI)
https://res.slu.se/id/publ/2007