Carnrot, Cecilia
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
Sammanfattning
Nineteen lipophilic thymidine phosphate-mimicking compounds were designed and synthesized as potential inhibitors of thymidine monophosphate kinase of Bacillus anthracis, a Gram-positive bacterium that causes anthrax. These thymidine analogues were substituted at the 5'-postion with sulfonamide-, amide-, (thio)urea-, or triazole groups, which served as lipophilic surrogates for phosphate. Three of the tested compounds produced inhibition of B. anthracis Sterne growth and/or thymidine monophosphate activity. Additional studies will be necessary to elucidate the potential of this type of B. anthracis thymidine monophosphate inhibitors as novel antibiotics in the treatment Of anthrax.
Nyckelord
bacillus anthracis thymidine monophosphate kinase (BaTMPK); 5'-modified; thymidine-based BaTMPK kinase inhibitors
Publicerad i
Nucleosides, Nucleotides and Nucleic Acids
2008, volym: 27, nummer: 3, sidor: 244-260
Utgivare: TAYLOR & FRANCIS INC
SLU författare
Eriksson, Staffan
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
Globala målen (SDG)
SDG3 God hälsa och välbefinnande
UKÄ forskningsämne
Veterinärmedicin
Husdjursvetenskap
Publikationens identifierare
- DOI: https://doi.org/10.1080/15257770701845238
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/20801