Pejler, Gunnar
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
Sammanfattning
When mast cells are activated they can respond by releasing their secretory granule compounds, including mast cell-specific proteases of chymase, tryptase and carboxypeptidase A (MC-CPA) type. MC-CPA is a dominant protein component of the mast cell granule and the MC-CPAgene is extremely highly expressed. Despite this, relatively little has been known of its biological function. However, the recent generation of mouse strains lacking MC-CPA has opened up new possibilities for investigations related to this protease. This recent development has revealed a role for MC-CPA in regulating innate immunity responses, including the degradation of harmful substances such as the vasoconstrictive factor endothelin 1 and snake venom toxins. Here, we summarize the current knowledge of MC-CPA.
Publicerad i
Trends in Immunology
2009, volym: 30, nummer: 8, sidor: 401-408
SLU författare
Knight, Stefan David
- Institutionen för molekylärbiologi, Sveriges lantbruksuniversitet
- Institutionen för molekylärbiologi, Sveriges lantbruksuniversitet
Wernersson, Sara
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
UKÄ forskningsämne
Husdjursvetenskap
Veterinärmedicin
Publikationens identifierare
- DOI: https://doi.org/10.1016/j.it.2009.04.008
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/27732