Sammanfattning
Oxytocin treatment in rats induces long-lasting antistress and growth promoting effects. This study investigated whether prolyl-leucyl-glycinamide (PLG) (the c-terminal tripeptide of oxytocin) or tocinoic acid (the ring structure of oxytocin) could induce some of these effects in male rats. For this purpose, PLG (2 or 10 mg/kg, s. c.) or tocinoic acid (1 mg/kg, s. c.) was administered to rats once a day for 3 or 5 days. Blood pressure, heart rate, spontaneous motor activity, nociceptive thresholds, and the survival of ischaemic musculocutaneous flaps were measured. In addition, endogenous oxytocin levels and plasma levels of some hormones known to be influenced by oxytocin were determined. PLG (2 mg/kg, s.c., but not 10 mg/kg, s.c.) decreased diastolic blood pressure (p
Nyckelord
oxytocin; MIF-1; PLG; tocinoic acid; nociceptive thresholds; blood pressure; spontaneous motor activity; lschaemic musculocutaneous flap; gastrin; cholecystokinin; corticosterone; ACTH
Publicerad i
Physiology and Behavior
2004, volym: 83, nummer: 3, sidor: 475-481
Utgivare: PERGAMON-ELSEVIER SCIENCE LTD
UKÄ forskningsämne
Neurovetenskaper
Publikationens identifierare
- DOI: https://doi.org/10.1016/j.physbeh.2004.08.034
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/3398