Sandström, Corine
- Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
Sammanfattning
Methylation is among the most widespread chemical modifications encountered in biomolecules and has a pivotal role in many major biological processes. In the biosynthetic pathway of the antibiotic thiostrepton A, we identified what is to our knowledge the first tryptophan methyltransferase. We show that it uses unprecedented chemistry to methylate inactivated sp(2)-hybridized carbon atoms, despite being predicted to be a radical SAM enzyme.
Publicerad i
Nature Chemical Biology
2012, volym: 8, nummer: 12, sidor: 957-959
Utgivare: NATURE PUBLISHING GROUP
SLU författare
UKÄ forskningsämne
Organisk kemi
Publikationens identifierare
- DOI: https://doi.org/10.1038/NCHEMBIO.1091
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/41971