Pejler, Gunnar
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
Sammanfattning
Here we show that mast cells contain dopamine and that mast cell activation causes dopamine depletion, indicating its presence within secretory granules. Dopamine storage increased during mast cell maturation from bone marrow precursors, and was dependent on the presence of serglycin. Moreover, the expression of tyrosine hydroxylase, the key enzyme in dopamine biosynthesis, was induced during mast cell maturation; histidine decarboxylase and tryptophan hydroxylase 1 were also induced. Mast cell activation caused a robust induction of histidine decarboxylase, but no stimulation of tyrosine hydroxylase or tryptophan hydroxylase 1 expression. The present study points toward a possible role of dopamine in mast cell function.
Nyckelord
dopamine; histidine decarboxylase; mast cells; serglycin; tryptophan hydroxylase; tyrosine hydroxylase
Publicerad i
Biological Chemistry
2012, volym: 393, nummer: 1-2, sidor: 107-112
Utgivare: WALTER DE GRUYTER & CO
SLU författare
Rönnberg, Elin
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
UKÄ forskningsämne
Molekylärbiologi
Immunologi
Biokemi
Publikationens identifierare
- DOI: https://doi.org/10.1515/BC-2011-220
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/42323