Sammanfattning
In a previous study of Mycobacterium tuberculosis complex isolates from Guinea-Bissau in West Africa, we identified a unique group of strains, designated here as the Guinea-Bissau family of strains, which, although genotypically closely related, phenotypically demonstrated a considerable heterogeneity. We conducted here a detailed genotypic analysis of a subset (n=35) of these isolates. Based on the data obtained, and by comparison of known corresponding genes in mycobacteria outside the M. tuberculosis complex, we propose that the Guinea-Bissau strains belong to a unique branch of the M. tuberculosis complex tree in between classical M. tuberculosis and classical M. bovis. These observations are discussed in their significance in M. tuberculosis complex classification. (C) 2004 Elsevier SAS. All rights reserved.
Nyckelord
tuberculosis; Africa; evolution
Publicerad i
Microbes and Infection
2004, volym: 6, nummer: 3, sidor: 272-278
Utgivare: ELSEVIER SCIENCE BV
UKÄ forskningsämne
Infektionsmedicin
Publikationens identifierare
- DOI: https://doi.org/10.1016/j.micinf.2003.12.006
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/4256