Differences in the ability to suppress interferon beta production between allele A and allele B NS1 proteins from H10 influenza A viruses

Abstract

Conclusions: These studies reveal that different non-structural protein 1 (NS1) of influenza viruses, one from allele A and another from allele B, show different abilities to suppress the type I interferon beta expression. It has been hypothesised that some of the differences in the different abilities of the alleles to suppress ISRE were because of the interactions and inhibitions at later stages from the IFN receptor, such as the JAK/STAT pathway. This might reflect the additional effects of the immune evasion potential of different NS1s.

Published in

Virology Journal
2010, volume: 7, pages: 1-8
Publisher: BIOMED CENTRAL LTD

SLU Authors

• Munir, Muhammad

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Metreveli, Giorgi

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Belak, Sandor

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Berg, Mikael

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Veterinary Science
Animal and Dairy Science

Publication identifier

• DOI: https://doi.org/10.1186/1743-422X-7-376

Permanent link to this page (URI)

https://res.slu.se/id/publ/47752