Differences in the ability to suppress interferon beta production between allele A and allele B NS1 proteins from H10 influenza A viruses

Sammanfattning

Conclusions: These studies reveal that different non-structural protein 1 (NS1) of influenza viruses, one from allele A and another from allele B, show different abilities to suppress the type I interferon beta expression. It has been hypothesised that some of the differences in the different abilities of the alleles to suppress ISRE were because of the interactions and inhibitions at later stages from the IFN receptor, such as the JAK/STAT pathway. This might reflect the additional effects of the immune evasion potential of different NS1s.

Publicerad i

Virology Journal
2010, volym: 7, sidor: 1-8
Utgivare: BIOMED CENTRAL LTD

SLU författare

• Munir, Muhammad

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Metreveli, Giorgi

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Belak, Sandor

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Berg, Mikael

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Veterinärmedicin
Husdjursvetenskap

Publikationens identifierare

• DOI: https://doi.org/10.1186/1743-422X-7-376

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/47752