Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

Smolders, Lucas A.; Meij, Björn P.; Onis, David; Riemers, Frank M.; Bergknut, Niklas; Wubbolts, Rickard; Grinwis, Guy C.M.; Houweling, Martin; Groot Koerkamp, Marian J.A.; van Lenen, Dik; Holstege, Frank; Hazewinkel, H.A.W.; Creemers, LB; Penning, LC; Tryfonidou, Marianna A.

doi:10.1186/ar4157

Research article2013Peer reviewedOpen access

Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

Smolders, Lucas A.; Meij, Björn P.; Onis, David; Riemers, Frank M.; Bergknut, Niklas; Wubbolts, Rickard; Grinwis, Guy C.M.; Houweling, Martin; Groot Koerkamp, Marian J.A.; van Lenen, Dik; Holstege, Frank; Hazewinkel, H.A.W.; Creemers, LB; Penning, LC; Tryfonidou, Marianna A.

Abstract

Conclusions: Early IVD degeneration involves down-regulation of canonical Wnt signaling and Caveolin-1 expression, which appears to be essential to the physiology and preservation of NCs. Therefore, Caveolin-1 may be regarded an exciting target for developing strategies for IVD regeneration.

Published in

Arthritis Research and Therapy
2013, volume: 15, number: 1
Publisher: BIOMED CENTRAL LTD

SLU Authors

Bergknut, Niklas
- Department of Clinical Sciences, Swedish University of Agricultural Sciences

UKÄ Subject classification

Other Veterinary Science

Publication identifier

DOI: https://doi.org/10.1186/ar4157

Permanent link to this page (URI)

https://res.slu.se/id/publ/50356