Effect of fluoropyrimidines on the growth of Ureaplasma urealyticum

Sammanfattning

In the present study, we investigated the effect of fluoropyrimidines on the growth of Ureaplasma urealyticum. Addition of fluoropyrimidines strongly inhibited bacterial growth. Growth inhibition by these analogues could be reversed by addition of either thymidine or deoxyuridine, suggesting inhibition of thymidylate biosynthesis as the mechanism in operation.

Nyckelord

Ureaplasma; nucleoside analogues; growth inhibition; fluoropyrimidines

Publicerad i

Nucleosides, Nucleotides and Nucleic Acids
2004, volym: 23, nummer: 8-9, sidor: 1499-1502

SLU författare

• Wehelie, Rahma

  • Institutionen för molekylär biovetenskap, Sveriges lantbruksuniversitet
    

• Eriksson, Staffan

  • Institutionen för molekylär biovetenskap, Sveriges lantbruksuniversitet
    

• Wang, Liya

  • Institutionen för molekylär biovetenskap, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Mikrobiologi inom det medicinska området

Publikationens identifierare

• DOI: https://doi.org/10.1081/NCN-200027714

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/53110