Gabrielsson, Johan
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Abstract
We study the dynamics of drug-target interaction and the way it impacts the shape of drug versus time graphs through the derivation of accurate closed-form approximations, which reveal explicitly the relevance of rate constants in the system and can be used to compute such critical quantities as the area under the ligand (drug) curve, the clearance and the terminal slope lambda (z) . We also use these approximations to verify the validity of well-known approximate models, in particular the rapid binding model (Mager and Krzyzanski, Pharm Res 22:1589-1596, 2005) and the quasi-steady state model (Gibiansky et al., J Pharmacokinet Pharmacodyn 35:573-591, 2008).
Keywords
Pharmacokinetics; Receptor-binding; Michaelis-Menten; Singular perturbations
Published in
Computational Geosciences
2013, volume: 17, number: 3, pages: 599-608
Publisher: SPRINGER
SLU Authors
UKÄ Subject classification
Computer Science
Geosciences, Multidisciplinary
Publication identifier
- DOI: https://doi.org/10.1007/s10596-012-9312-4
Permanent link to this page (URI)
https://res.slu.se/id/publ/54141