Gabrielsson, Johan
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
Sammanfattning
We study the dynamics of drug-target interaction and the way it impacts the shape of drug versus time graphs through the derivation of accurate closed-form approximations, which reveal explicitly the relevance of rate constants in the system and can be used to compute such critical quantities as the area under the ligand (drug) curve, the clearance and the terminal slope lambda (z) . We also use these approximations to verify the validity of well-known approximate models, in particular the rapid binding model (Mager and Krzyzanski, Pharm Res 22:1589-1596, 2005) and the quasi-steady state model (Gibiansky et al., J Pharmacokinet Pharmacodyn 35:573-591, 2008).
Nyckelord
Pharmacokinetics; Receptor-binding; Michaelis-Menten; Singular perturbations
Publicerad i
Computational Geosciences
2013, volym: 17, nummer: 3, sidor: 599-608
Utgivare: SPRINGER
SLU författare
UKÄ forskningsämne
Datavetenskap (datalogi)
Multidisciplinär geovetenskap
Publikationens identifierare
- DOI: https://doi.org/10.1007/s10596-012-9312-4
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/54141