Sun, Ren
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
Sammanfattning
Conclusion: We have shown that several anticancer and antiviral nucleoside and nucleobase analogs are potent inhibitors of Mpn growth and that the mechanism of inhibition are most likely due to inhibition of enzymes in the nucleotide biosynthesis pathway and nucleoside transporter. Our results suggest that enzymes in Mycoplasma nucleotide biosynthesis are potential targets for future design of antibiotics against Mycoplasma infection.
Nyckelord
Mycoplasma pneumoniae; Growth inhibition; 6-thioguanine; Trifluorothymidine; Hypoxanthine guanine phosphoribosyl transferase; Thymidine kinase
Publicerad i
BMC Microbiology
2013, volym: 13, artikelnummer: 184
Utgivare: BIOMED CENTRAL LTD
SLU författare
Wang, Liya
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
Associerade SLU-program
AMR: Bakterier
Globala målen (SDG)
SDG3 God hälsa och välbefinnande
UKÄ forskningsämne
Mikrobiologi inom det medicinska området
Publikationens identifierare
- DOI: https://doi.org/10.1186/1471-2180-13-184
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/55281