Pejler, Gunnar
- Institutionen för molekylär biovetenskap, Sveriges lantbruksuniversitet
Sammanfattning
We have previously shown that actinonin causes inhibition of cellular proliferation in U937 leukemia cells. In this report we demonstrate that the inhibition of cell growth by actinonin occurs through the induction of apoptosis. Signs of apoptosis at high actinonin concentration included DNA fragmentation, exposure of phosphatidylserine and condensation of cell nuclei. Apoptosis caused by actinonin was inhibited by Z-VAD-FMK, a broad specificity inhibitor of caspases, implicating the caspase pathway of apoptosis. Further, apoptosis was associated with a large increase in intracellular caspase-3 and -7 activities. (c) 2004 Elsevier Ireland Ltd. All rights reserved
Publicerad i
Cancer Letters
2005, volym: 223, nummer: 2, sidor: 211-218
Utgivare: ELSEVIER IRELAND LTD
SLU författare
Grujic, Mirjana
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
UKÄ forskningsämne
Cell- och molekylärbiologi
Publikationens identifierare
- DOI: https://doi.org/10.1016/j.caclet.2004.10.048
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/5772