The X proteins of bornaviruses interfere with type I interferon signalling

Sammanfattning

Borna disease virus (BDV) is a neurotropic, negative-stranded RNA virus causing persistent infection and progressive neurological disorders in a wide range of warm-blooded animals. The role of the small non-structural X protein in viral pathogenesis is not completely understood. Here we investigated whether the X protein of BDV and avian bornavirus (ABV) interferes with the type I interferon (IFN) system, similar to other non-structural proteins of negative-stranded RNA viruses. In luciferase reporter assays, we found that the X protein of various bornaviruses interfered with the type I IFN system at all checkpoints investigated, in contrast to previously reported findings, resulting in reduced type I IFN secretion.

Publicerad i

Journal of General Virology
2013, volym: 94, nummer: pt 2, sidor: 263-269

SLU författare

• Johansson Wensman, Jonas

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    
  • Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
    

• Munir, Muhammad

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Blomström, Anne-Lie

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Berg, Mikael

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Patobiologi
Mikrobiologi inom det medicinska området
Immunologi inom det medicinska området

Publikationens identifierare

• DOI: https://doi.org/10.1099/vir.0.047175-0

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/57724