A MATHEMATICAL MODEL OF HUMAN THYMIDINE KINASE 2 ACTIVITY

Sammanfattning

The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of 0.5 (apparent negative cooperativity) for dT and 1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.

Nyckelord

Thymidine kinase 2; mathematical model

Publicerad i

Nucleosides, Nucleotides and Nucleic Acids
2011, volym: 30, nummer: 3, sidor: 203-209
Utgivare: TAYLOR & FRANCIS INC

SLU författare

• Wang, Liya

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Eriksson, Staffan

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Biokemi
Molekylärbiologi

Publikationens identifierare

• DOI: https://doi.org/10.1080/15257770.2011.563765

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/57735