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Sammanfattning

Interindividual differences in many behaviors are partly due to genetic differences, but the identification of the genes and variants that influence behavior remains challenging. Here, we studied an F-2 intercross of two outbred lines of rats selected for tame and aggressive behavior toward humans for >64 generations. By using a mapping approach that is able to identify genetic loci segregating within the lines, we identified four times more loci influencing tameness and aggression than by an approach that assumes fixation of causative alleles, suggesting that many causative loci were not driven to fixation by the selection. We used RNA sequencing in 150 F-2 animals to identify hundreds of loci that influence brain gene expression. Several of these loci colocalize with tameness loci and may reflect the same genetic variants. Through analyses of correlations between allele effects on behavior and gene expression, differential expression between the tame and aggressive rat selection lines, and correlations between gene expression and tameness in F-2 animals, we identify the genes Gltscr2, Lgi4, Zfp40, and Slc17a7 as candidate contributors to the strikingly different behavior of the tame and aggressive animals.

Publicerad i

Genetics
2014, volym: 198, nummer: 3, sidor: 1277-1290
Utgivare: GENETICS SOCIETY AMERICA

SLU författare

UKÄ forskningsämne

Etologi
Bioinformatik och beräkningsbiologi (Metodutveckling under 10203)

Publikationens identifierare

  • DOI: https://doi.org/10.1534/genetics.114.168948

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/66331