Skip to main content
SLU publication database (SLUpub)

Abstract

Here, we report the isolation of a type 1 porcine reproductive and respiratory syndrome virus (PRRSV) strain from a clinical outbreak of severe respiratory problems and high fever. Next-generation sequencing was used to determine the complete genome sequence of the isolate (9625/2012). The virus belongs to a new branch within subtype 1, clade D, and shows the highest similarity to PRRSV Olot/1991 and to the Amervac vaccine strain. Mutation analysis of 9625/2012 revealed no evidence of recombination but did show a high proportion of amino acid substitutions in the putative neutralizing epitopes, suggesting an important role of selective immune pressure in the evolution of PRRSV 9625/2012.

Keywords

PRRSV; Sequencing; Complete genome; Epitope

Published in

Archives of Virology
2015, volume: 160, number: 2, pages: 417-422

SLU Authors

  • Balint, Adam

    • Veterinary Diagnostic Directorate

  • Zadori, Zoltan

    • Hungarian Academy of Sciences

UKÄ Subject classification

Medical Bioscience

Publication identifier

  • DOI: https://doi.org/10.1007/s00705-014-2265-2

Permanent link to this page (URI)

https://res.slu.se/id/publ/67642