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Sammanfattning

Here, we report the isolation of a type 1 porcine reproductive and respiratory syndrome virus (PRRSV) strain from a clinical outbreak of severe respiratory problems and high fever. Next-generation sequencing was used to determine the complete genome sequence of the isolate (9625/2012). The virus belongs to a new branch within subtype 1, clade D, and shows the highest similarity to PRRSV Olot/1991 and to the Amervac vaccine strain. Mutation analysis of 9625/2012 revealed no evidence of recombination but did show a high proportion of amino acid substitutions in the putative neutralizing epitopes, suggesting an important role of selective immune pressure in the evolution of PRRSV 9625/2012.

Nyckelord

PRRSV; Sequencing; Complete genome; Epitope

Publicerad i

Archives of Virology
2015, volym: 160, nummer: 2, sidor: 417-422

SLU författare

  • Balint, Adam

    • Veterinary Diagnostic Directorate

  • Zadori, Zoltan

    • Magyar Tudományos Akadémia

UKÄ forskningsämne

Medicinsk biovetenskap

Publikationens identifierare

  • DOI: https://doi.org/10.1007/s00705-014-2265-2

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/67642