NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery

Sammanfattning

Bunyaviruses have evolved a variety of strategies to counteract the antiviral defence systems of mammalian cells. Here we show that the NSs protein of Schmallenberg virus (SBV) induces the degradation of the RPB1 subunit of RNA polymerase II and consequently inhibits global cellular protein synthesis and the antiviral response. In addition, we show that the SBV NSs protein enhances apoptosis in vitro and possibly in vivo, suggesting that this protein could be involved in SBV pathogenesis in different ways.

Publicerad i

Journal of General Virology
2014, volym: 95, sidor: 1640-1646
Utgivare: SOC GENERAL MICROBIOLOGY

SLU författare

• Blomström, Anne-Lie

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    
  • University of Glasgow

UKÄ forskningsämne

Mikrobiologi inom det medicinska området
Folkhälsovetenskap, global hälsa och socialmedicin
Epidemiologi

Publikationens identifierare

• DOI: https://doi.org/10.1099/vir.0.065425-0

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/67996