Sandström, Corine
- Institutionen för kemi och bioteknologi, Sveriges lantbruksuniversitet
Sammanfattning
Gynostemrna pentaphyllum (GP) is a traditional Chinese medicine but is also consumed as tea by healthy people for its many beneficial effects. The herb is known for its anti-diabetic effect and immuno-modulatory properties. In patients with diabetes, the incidence of infections, including urinary tract infections, is increased and a common cause for antibiotic treatment. We hypothesized that GP could exhibit a beneficial impact on innate immunity in the urinary tract, thereby fighting such bacterial infections. Our aim was therefore to investigate whether orally taken GP would act on the urinary tract and modulate immune reactions in bladder epithelial cells. The extract was analyzed by NMR and was found to consist almost exclusively of a mixture of several saponins present in different concentrations. Ex vivo infection experiments demonstrated that the pro-inflammatory response to Escherichia coli was attenuated in bladder tissue from diabetic rats receiving GP compared to diabetic animals without treatment. In vitro assays using uroepithelial cells challenged with E. coli corroborated these results. Moreover, GP treatment modulated the expression of antimicrobial peptides. With these properties, GP might be a beneficial supplement for diabetic patients with history of urinary tract infections. (C) 2015 Elsevier Ltd. All rights reserved.
Nyckelord
Diabetes mellitus; Urinary tract infection; Innate immune response; Medicinal herb; Antimicrobial peptides
Publicerad i
Journal of Functional Foods
2015, volym: 17, sidor: 283-292
Utgivare: ELSEVIER SCIENCE BV
SLU författare
Globala målen (SDG)
SDG3 God hälsa och välbefinnande
UKÄ forskningsämne
Analytisk kemi
Övrig annan medicin och hälsovetenskap
Publikationens identifierare
- DOI: https://doi.org/10.1016/j.jff.2015.03.028
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/69713