Skip to main content
SLU:s publikationsdatabas (SLUpub)

Sammanfattning

Recently, decreased activity levels have been observed in pigs treated postoperatively with transdermal delivery of fentanyl (TD-fentanyl) after isoflurane anaesthesia. Whether the change in behaviour is related to opioid-induced sedation or to insufficient pain relief remains to be investigated. This study was therefore undertaken to evaluate the effect of TD-fentanyl 50 mu g h(-1) on the activity level with and without isollurane anaesthesia. Eight pigs (25.4 +/- 5.2 kg) were submitted to a cross-over study and given two treatments; 1) fentanyl patch applied after 30 minutes of anaesthesia (treatment A/F) and 2) fentanyl patch without anaesthesia (treatment F). The pigs' behaviour was observed from a video recording instantaneously every 10 minutes for 24 h before treatments and up to 72 h after the patch attachment. Venous blood samples were taken 1, 6, 12, 24, 48 and 72 h after the patch application. The behaviour recordings showed that TD-fentanyl did not produce sedation in any pig, No differences were found between the two treatments in activity level, weight gain or serum fentanyl concentration. This concentration measured after 24 h was 0.27 +/- 0.11 ng ml(-1) and 0.47 +/- 0.40 ng ml(-1) in the A/F and F group, respectively. In conclusion, transdermal delivery of 50 mu g h(-1) fentanyl did not cause inactivity in growing pigs. However, the large variations in serum fentanyl concentration indicate that drug absorption from transdermal patches is unpredictable and sometimes deficient

Publicerad i

Acta Veterinaria Scandinavica
2005, volym: 46, nummer: 3, sidor: 149-157
Utgivare: DANSKE DYRLAEGEFORENING

SLU författare

UKÄ forskningsämne

Husdjursvetenskap
Veterinärmedicin

Publikationens identifierare

  • DOI: https://doi.org/10.1186/1751-0147-46-149

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/7211