The Polycomb Group Protein Regulatory Network

Sammanfattning

Correct expression of specific sets of genes in time and space ensures the establishment and maintenance of cell identity, which is required for proper development of multicellular organisms. Polycomb and Trithorax group proteins form multisubunit complexes that antagonistically act in epigenetic gene repression and activation, respectively. The traditional view of Polycomb repressive complexes (PRCs) as executors of long-lasting and stable gene repression is being extended by evidence of flexible repression in response to developmental and environmental cues, increasing the complexity of mechanisms that ensure selective and properly timed PRC targeting and release of Polycomb repression. Here, we review advances in understanding of the composition, mechanisms of targeting, and function of plant PRCs and discuss the parallels and differences between plant and animal models.

Nyckelord

Polycomb repressive complex; epigenetics; gene repression; plant development; Trithorax

Publicerad i

Annual Review of Plant Biology
2015, volym: 66, sidor: 269-296
Utgivare: ANNUAL REVIEWS, 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA

SLU författare

• Mozgova, Iva

  • Institutionen för växtbiologi, Sveriges lantbruksuniversitet
    

• Hennig, Lars

  • Institutionen för växtbiologi, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Utvecklingsbiologi
Evolutionsbiologi

Publikationens identifierare

• DOI: https://doi.org/10.1146/annurev-arplant-043014-115627

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/72374