Ström Holst, Bodil
- Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
Sammanfattning
Background: Testicular tumours are common in dogs and in many cases do not give rise to clinical signs. In other cases, signs of feminization, hyperpigmentation or alopecia may be observed, most commonly associated with Sertoli cell tumours (SCT). Although these signs are often associated with elevated concentrations of oestradiol, analysis of oestradiol may give inconclusive results due to large variations among individuals. Other biomarkers are therefore needed. Anti-Mullerian hormone (AMH) is expressed by the Sertoli cell. In humans, AMH has been shown to be a specific marker of Sertoli cell origin in gonadal tumours. Using immunohistochemistry, AMH has been shown to be a useful marker of immature and neoplastic Sertoli cells in dogs. The aim of the present study was to evaluate the clinical relevance of AMH analysis in peripheral blood in the diagnostic workup of dogs with suspected testicular tumours.Results: Blood was collected from 20 dogs with a palpable testicular mass and from 27 healthy controls. Serum was analysed for oestradiol-17 beta using a RIA and for AMH using an ELISA. The Mann-Whitney U test was used to compare hormone concentrations between different groups.All control dogs had AMH concentrations
Nyckelord
Anti-Mullerian hormone; Dog; Neoplasia; Sertoli cell; Testis
Publicerad i
BMC Veterinary Research
2015, volym: 11, artikelnummer: 166
Utgivare: BIOMED CENTRAL LTD
SLU författare
UKÄ forskningsämne
Annan veterinärmedicin
Publikationens identifierare
- DOI: https://doi.org/10.1186/s12917-015-0487-5
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/74258